ShowMenu
2017年9月23日 星期六  
 
 
熊兵

 
姓 名
 熊兵
性 别
 男
出生年月
 1975.3
学 历
 博士
毕业时间
 2003
专 业
 有机化学
电 话
 021-50806600
邮 编
 201203
E-Mail
 bxiong@mail.shcnc.ac.cn
单 位
中国科学院上海药物研究所
通信地址
 上海浦东张江祖冲之路555号
个人简历:

 

2005.12---至今     中国科学院上海药物研究所;副研究员,研究员,博士生导师

2003.10-2005.12   加拿大McGill大学结构生物学中心

2000.9-2003.7 中国科学院上海药物研究所 理学博士

研究方向:

主要从事分子识别及药物分子设计/合成工作:

1,通过采用模型分子的合成、结构确定,以及对结构数据库统计分析和分子模拟等多种方法的综合应用,期望从分子间力的本质上对药物与靶标大分子之间的作用进行研究,从而开展理性药物设计和合成工作。

2,通过对多个靶标家族进行组合库设计和基于分子片段的药物设计/合成工作,开展新药研究工作。

通过模型化合物、光谱学、分子模拟等方法研究分子间作用力和分子识别,同时采用结构数据库对分子作用进行统计分析,在药物分子、靶点研究方面建立了多个同药物化学紧密联系的药物设计软件、数据库系统。相关研究结果已发表在Bioinformatics、BMC Bioinformatics、journal of computer information and modeling、JBC、Proteins等重要期刊上。药物研发相关工作中,采用结构生物学研究方法,对一些重要靶标蛋白的进行了晶体结构测定,开展基于结构的药物设计和基于片段的药物设计,结合药物合成研究,进行药物研发。相关工作已发表在PLOS One, Bioorg. Med. Chem. Lett.、Bioorg. Med. Chem.、JMC等多个重要期刊上。近年来已发表论文三十余篇,获授权专利多项。

 

奖励和荣誉:

中国科学院知识创新工程青年人才项目(2011年)

中国药学会-施维雅青年药物化学奖(第15届)

发表文章:

5年(2007-2012

1.         Xia G, Liu L, Xue M, Liu H, Yu J, Li P, Chen Q, Xiong B, Liu X, Shen J.Discovery of novel sulfonamides as potent and selective inhibitors against human and mouse 11β-hydroxysteroid dehydrogenase type 1. Mol Cell Endocrinol. 2012. DOI: 10.1016/j.mce.2012.02.017

2.         Zheng, M.#, Xiong, B.#, Luo, C., Li, S., Liu, X., Shen, Q., Li, J., Zhu, W., Luo, X. & Jiang, H. (2011). Knowledge-based scoring functions in drug design: 3. A two-dimensional knowledge-based hydrogen-bonding potential for the prediction of protein-ligand interactions. J Chem Inf Model 51, 2994-3004.

3.         Zhang, Z., Meng, T., Yang, N., Wang, W., Xiong, B., Chen, Y., Ma, L., Shen, J., Miao, Z. H. & Ding, J. (2011). MT119, a new planar-structured compound, targets the colchicine site of tubulin arresting mitosis and inhibiting tumor cell proliferation. Int J Cancer 129, 214-24.

4.         Xia, G., Xue, M., Liu, L., Yu, J., Liu, H., Li, P., Wang, J., Li, Y., Xiong, B.* & Shen, J. (2011). Potent and novel 11beta-HSD1 inhibitors identified from shape and docking based virtual screening. Bioorg Med Chem Lett 21, 5739-44.

5.         Shen, Q.#, Xiong, B.#, Zheng, M., Luo, X., Luo, C., Liu, X., Du, Y., Li, J., Zhu, W., Shen, J. & Jiang, H. (2011). Knowledge-based scoring functions in drug design: 2. Can the knowledge base be enriched? J Chem Inf Model 51, 386-97.

6.         Fong, D. H.#, Xiong, B.#, Hwang, J. & Berghuis, A. M. (2011). Crystal structures of two aminoglycoside kinases bound with a eukaryotic protein kinase inhibitor. PLoS One 6, e19589.

7.         Zhang, Z., Meng, T., He, J., Li, M., Tong, L. J., Xiong, B., Lin, L., Shen, J., Miao, Z. H. & Ding, J. (2010). MT7, a novel compound from a combinatorial library, arrests mitosis via inhibiting the polymerization of microtubules. Invest New Drugs 28, 715-28.

8.         Xue, M., Zheng, M., Xiong, B.*, Li, Y., Jiang, H. & Shen, J. (2010). Knowledge-based scoring functions in drug design. 1. Developing a target-specific method for kinase-ligand interactions. J Chem Inf Model 50, 1378-86.

9.         Xiong, B.*, Wu, J., Burk, D. L., Xue, M., Jiang, H. & Shen, J. (2010). BSSF: a fingerprint based ultrafast binding site similarity search and function analysis server. BMC Bioinformatics 11, 47.

10.        Meng, T., Wang, J., Peng, H., Fang, G., Li, M., Xiong, B., Xie, X., Zhang, Y., Wang, X. & Shen, J. (2010). Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure-based approach. Eur J Med Chem 45, 1133-9.

11.        Ling, Q., Zhou, Y. Y., Cai, Z. L., Zhang, Y. H., Xiong, B., Ma, L. P., Wang, X., Li, X., Li, J. & Shen, J. K. (2010). Synthesis and LAR inhibition of 7-alkoxy analogues of illudalic acid. Yao Xue Xue Bao 45, 1385-97.

12.        Fong, D. H., Lemke, C. T., Hwang, J., Xiong, B. & Berghuis, A. M. (2010). Structure of the antibiotic resistance factor spectinomycin phosphotransferase from Legionella pneumophila. J Biol Chem 285, 9545-55.

13.        Du, Y., Li, Q., Xiong, B., Hui, X., Wang, X., Feng, Y., Meng, T., Hu, D., Zhang, D., Wang, M. & Shen, J. (2010). Aromatic beta-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists. Bioorg Med Chem 18, 4255-68.

14.        Zhu, Y. P., Xiao, K., Yu, H. P., Ma, L. P., Xiong, B., Zhang, H. Y., Wang, X., Li, J. Y., Li, J. & Shen, J. K. (2009). Discovery of potent beta-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing hybrids. Acta Pharmacol Sin 30, 259-69.

15.        Zhu, Y., Xiao, K., Ma, L., Xiong, B., Fu, Y., Yu, H., Wang, W., Wang, X., Hu, D., Peng, H., Li, J., Gong, Q., Chai, Q., Tang, X., Zhang, H. & Shen, J. (2009). Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta-secretase. Bioorg Med Chem 17, 1600-13.

16.        Zhang, J., Xiong, B., Zhen, X. & Zhang, A. (2009). Dopamine D1 receptor ligands: where are we now and where are we going. Med Res Rev 29, 272-94.

17.        Yan, B. B., Xue, M. Z., Xiong, B.*, Liu, K., Hu, D. Y. & Shen, J. K. (2009). ScafBank: a public comprehensive Scaffold database to support molecular hopping. Acta Pharmacol Sin 30, 251-8.

18.        Xiong, B., Liu, K., Wu, J., Burk, D. L., Jiang, H. & Shen, J. (2008). DrugViz: a Cytoscape plugin for visualizing and analyzing small molecule drugs in biological networks. Bioinformatics 24, 2117-8.

19.        Xiong, B., Burk, D. L., Shen, J., Luo, X., Liu, H. & Berghuis, A. M. (2008). The type IA topoisomerase catalytic cycle: A normal mode analysis and molecular dynamics simulation. Proteins 71, 1984-94.

20.        Ling, Q., Huang, Y., Zhou, Y., Cai, Z., Xiong, B., Zhang, Y., Ma, L., Wang, X., Li, X., Li, J. & Shen, J. (2008). Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action. Bioorg Med Chem 16, 7399-409.

21.        Zhang, L., Qiu, B., Xiong, B., Li, X., Li, J., Wang, X. & Shen, J. (2007). Quinoxalinylurea derivatives as a novel class of JSP-1 inhibitors. Bioorg Med Chem Lett 17, 2118-22.

22.        Pang, T., Xiong, B., Li, J. Y., Qiu, B. Y., Jin, G. Z., Shen, J. K. & Li, J. (2007). Conserved alpha-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits. J Biol Chem 282, 495-506.

 

 

目前承担和参与项目:

国家自然基金委项目2项,中科院项目2项

社会兼职:

山东轻工业学院 化学专业

打印】【关闭