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2017年11月19日 星期日  
 
 
刘波

个人简历:

2001.9-2004.7     于山东农业大学获植物学硕士学位

2004.9-2007.7     于山东大学微生物技术国家重点实验室获微生物学博士学位

2007.7-2009.3     山东轻工业学院食品与生物工程学院副教授

2009.     3-2010.12 美国弗吉尼亚大学医学院生理与生物物理系 博士后,访问学者

2010.12-       齐鲁工业大学食品与生物工程学院副教授,校聘教授

 

 

研究方向:

 

蛋白质的结构与功能

 

蛋白质分子设计与改造

 

工业用微生物酶的开发及利用

 

 

代表性论文:* 通讯作者

1. Yanyan Gao, Ying Jiang, Qiulei Liu, Ruiming Wang, Xinli Liu, Bo Liu*. (2014) Enzymatic and regulatory properties of the Trehalose-6-phosphate synthase from the thermoacidophilic archaeon Thermoplasma acidophilum. Biochimie 101:215-220   (SCI, IF=3.123)

2. Tianming Liu, Lujiang Hao, Ruiming Wang, Bo Liu*. (2013) Molecular characterization of a thermostable aldehyde dehydrogenase (ALDH) from the hyperthermophilic archaeon Sulfolobus tokodaii strain 7. Extremophiles 17(1):181-90    (SCI, IF=2.174) 

3. Qiulei Liu, Lei Li, Liu Yang, Tianming Liu, Chenggu Cai, Bo Liu*. Modification of the sweetness and stability of sweet-tasting protein monellin by gene mutation and protein engineering. Biomed Res Int, 2016, 2016:3647173 (SCI, IF=1.579)

4. Tianming Liu, Yulong Shen, Qingjun Liu, Bo Liu*. (2008) The unique Entner-Doudoroff (ED) glycolysis pathway of glucose in Archaea. Acta Microbiologica Sinica 48(8):1126-1131

5.  刘秋蕾, 王飞, 李磊, 刘波*. 甜味分子与G蛋白偶联受体Tas1R2/3的相互作用及激活机制. 生命的化学2014, 34:500-505

6. Bo Liu, Matthew Ha, Xuanyu Meng, Tanno Kaur, Mohammed Khaleduzzaman, Zhe Zhang, Peihua Jiang, Xia Li, Meng Cui. (2011) Molecular mechanism of species-dependent sweet taste toward artificial sweeteners. Journal of neuroscience 31(30):11070-11076  (SCI, IF=6.747) 被引用次数:21

7. Bo Liu, Ye Hong, Lei Wu, Zhuo Li, Jinfeng Ni, Duohong Sheng, Yulong Shen. (2007) A unique highly thermostable 2-phosphoglycerate forming glycerate kinase from the hyperthermophilic archaeon Pyrococcus horikoshiigene cloning, expression and characterization. Extremophiles 11(5):733-739 (SCI, IF=2.174) 被引用次数:9

8. Bo Liu, Matthew Ha, Xuanyu Meng, Mohammed Khaleduzzaman, Zhe Zhang,  Xia LiMeng Cui. (2012) Functional characterization of the heterodimeric sweet taste receptor T1R2 and T1R3 from a New World monkey species (squirrel monkey) and its response to sweet-tasting proteins. Biochemical and Biophysical Research Communications 427(2):431-437 (SCI, IF=2.281) 被引用次数:2

9. Bo Liu, Zhuo Li, Ye Hong, Jinfeng Ni, Duohong Sheng, Yulong Shen. (2006) Cloning, expression and characterization of a exo-D-glucosaminidase from the hyperthermophilic archaeon Pyroco thermorstable ccus horikoshii. Biotechnology Letters 28(20):1655-1660 (SCI, IF=1.964) 被引用次数:8

10. Bo Liu, Lei Wu, Tianming Liu, Ye Hong, Yulong Shen, Jinfeng Ni. (2009) A MOFRL family glycerate kinase from the thermophilic crenarchaeon, Sulfolobus tokodaii, with unique enzymatic properties. Biotechnology Letters 31(12):1937-194 (SCI, IF=1.964)  被引用次数:7

 

发明专利:

一种嗜热耐高温的甘油酸激酶及其制备方法与应用。专利号:ZL2006 1 0068967.9,授权日期:2009.8.19,发明人:申玉龙,刘波

 

目前承担项目:

1. 国家自然科学基金项目(30900039): 古菌Sulfolobus tokodaii甘油醛脱氢酶及其对非磷酸化Entner-Doudoroff糖酵解代谢的调控机制,主持 (2010- 2012)

2. 国家自然科学基金面上项目(31271118):甜味蛋白质大分子味觉感知及其激活甜味受体-G蛋白偶联受体(GPCRT1R2/3的分子机制,主持(2013-2016);

3. 山东省优秀中青年科学家科研奖励基金项目(BS2012SW016):酶法生产氨基葡萄糖的工艺研究,主持(2013-2015);

4. 山东大学微生物技术国家重点实验室开放课题:嗜热酶的耐热机制,主持(2009- 2011)

 

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